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Related Experiment Video

Updated: May 7, 2026

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

Inflammatory cytokine network in schizophrenia.

Roksana Zakharyan¹, Anna Boyajyan

¹Institute of Molecular Biology NAS RA , Yerevan , Armenia.

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry

|September 18, 2013

Summary

Inflammation and inflammatory cytokines play a role in schizophrenia development. Targeting these cytokines could offer new therapeutic strategies for schizophrenia treatment.

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Last Updated: May 7, 2026

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

Area of Science:

Neuroscience
Psychiatry
Immunology

Background:

Schizophrenia is a complex psychiatric disorder with a multifactorial etiology.
Emerging evidence suggests a link between inflammatory processes and schizophrenia pathogenesis.

Purpose of the Study:

To review and synthesize existing literature on the involvement of inflammation and inflammatory cytokines in schizophrenia.
To discuss the role of these factors in the development and progression of the disease.

Main Methods:

Conducted an electronic literature search of peer-reviewed English language articles using PubMed.
Included previously published articles by the authors to supplement the review.

Main Results:

Observed significant alterations in mRNA and protein expression of proinflammatory and chemotactic cytokines in schizophrenia patients.
Noted that some observed cytokine alterations are genetically determined.
Acknowledged variability in findings based on study populations.

Conclusions:

Altered inflammatory cytokine production, influenced by genetic and environmental factors, contributes to low-grade systemic inflammation in schizophrenia.
Proinflammatory and chemotactic cytokines and their receptors are potential therapeutic targets for schizophrenia.