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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

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Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Published on: February 13, 2016

Controlling release from pH-responsive microcapsules.

Alireza Abbaspourrad1, Sujit S Datta, David A Weitz

  • 1Department of Physics and SEAS, Harvard University , Cambridge, Massachusetts 02138, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|September 18, 2013
PubMed
Summary
This summary is machine-generated.

We developed a microfluidic method to create uniform pH-responsive microcapsules. These capsules precisely control the release of active materials based on pH triggers, time delays, and release rates.

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Biotechnology

Background:

  • Microcapsules are widely used for active material encapsulation.
  • Controlling the release kinetics of encapsulated materials is crucial for many applications.
  • Existing methods often lack precise control over release triggers, timing, and rates.

Purpose of the Study:

  • To develop a microfluidic approach for producing monodisperse pH-responsive microcapsules.
  • To achieve precise control over the release behavior of encapsulated active materials.
  • To independently tune the trigger pH, release time delay, and release rate.

Main Methods:

  • Utilized microfluidics to fabricate microcapsules with controlled shell thickness.
  • Employed biocompatible pH-responsive polymers for microcapsule shell construction.
  • Created hybrid shells by mixing pH-responsive and pH-unresponsive polymers to modulate release rates.

Main Results:

  • Successfully produced monodisperse pH-responsive microcapsules.
  • Demonstrated independent control over trigger pH by polymer selection.
  • Achieved precise control over release time delay via shell thickness.
  • Independently controlled release rate by varying polymer composition in hybrid shells.

Conclusions:

  • The microfluidic approach offers robust encapsulation and triggered release of active materials.
  • This technology enables tunable release profiles for pH-responsive microcapsules.
  • The developed method provides a versatile platform for controlled delivery applications.