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Related Experiment Video

Updated: May 7, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Program-specific cost-effectiveness analysis: breast cancer screening policies for a safety-net program.

Joy Melnikow¹, Daniel J Tancredi, Zhuo Yang

¹Center for Healthcare Policy and Research, University of California, Davis, Sacramento, CA, USA.

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research

|September 18, 2013

Summary

Biennial mammography screening for women aged 50-64 is the most cost-effective breast cancer strategy. This approach maximizes life-years gained, even with budget constraints, offering a vital public health policy insight.

Keywords:

breast cancer screening cost-effectiveness analysis health policy safety net programs

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Last Updated: May 7, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Area of Science:

Health Economics
Public Health Policy
Cancer Screening

Background:

California's Every Woman Counts (EWC) program faced budget cuts and policy decisions.
Mammography screening policies significantly impact program costs and outcomes.

Purpose of the Study:

To evaluate cost-effectiveness of mammography policy options for the EWC program.
To inform policy choices regarding screening age, frequency, and technology.

Main Methods:

A microsimulation model assessed costs, outcomes, and cost-effectiveness.
Data from program claims, cancer registries, and literature informed model inputs.
Key outcomes included procedures, cancers, deaths, costs, and life-years gained.

Main Results:

Biennial film mammography (ages 50-64) reduced mortality by 7.8% at $18,999/life-year.
Annual screening or digital mammography showed higher costs per life-year.
Biennial digital mammography (ages 50-64) cost $17,050/life-year.

Conclusions:

Biennial screening mammography starting at age 50 is the most cost-effective EWC strategy.
Digital mammography's impact on life expectancy was minimal compared to film.
Program-specific cost-effectiveness analysis aids policymakers in resource allocation.