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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: May 7, 2026

Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
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Single pulse TMS differentially modulates reward behavior.

Arielle D Stanford1, Bruce Luber, Layla Unger

  • 1Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Institute for the Neurosciences, Room 117, Boston, MA 02115, USA.

Neuropsychologia
|September 18, 2013
PubMed
Summary
This summary is machine-generated.

Transcranial magnetic stimulation (TMS) to the inferior parietal lobe (IPL) slowed reaction times more than targeting the supplemental motor area (SMA). This suggests TMS may modulate reward processing deficits in psychiatric conditions.

Keywords:
Brain stimulationInferior parietal lobeMonetary incentive delay taskMotivationSupplementary motor areaTMSfMRI

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Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Understanding brain regions in reward processing is crucial for treating drive-related symptoms like avolition and apathy.
  • Transcranial magnetic stimulation (TMS) is a potential therapeutic tool for these conditions.

Purpose of the Study:

  • To investigate the effects of single-pulse TMS on reward processing and drive in healthy subjects.
  • To compare the impact of TMS targeting the inferior parietal lobe (IPL) versus the supplemental motor area (SMA).

Main Methods:

  • Fifteen healthy subjects underwent fMRI-guided single-pulse TMS to either the IPL or SMA during a monetary incentive delay task (MID).
  • Reaction times (RT) were measured to assess task performance and the effects of TMS.

Main Results:

  • Increasing reward magnitude led to decreased reaction times.
  • TMS pulses to the IPL significantly slowed RTs more than those to the SMA during the delay period.
  • This slowing effect persisted in subsequent trials after IPL stimulation compared to SMA stimulation.

Conclusions:

  • Both the SMA and IPL are implicated in reward processing, exhibiting opposing effects on RT modulation via TMS.
  • Targeting these cortical regions with TMS may offer a method for modulating reward circuit deficits in psychiatric populations.