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Related Concept Videos

Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

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Updated: May 7, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
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A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Cushing's disease in 2012.

Gabriel Obiols Alfonso1, Betina Biagetti Biagetti1, Ana Chacón Oreja2

  • 1Servicio de Endocrinología y Nutrición, Hospital Vall d'Hebron, Barcelona, España.

Endocrinologia Y Nutricion : Organo De La Sociedad Espanola De Endocrinologia Y Nutricion
|September 18, 2013
PubMed
Summary

This review summarizes key research on Cushing's disease from 2011-2012, covering quality of life, clinical aspects, comorbidities, diagnosis, and treatment options for this rare endocrine disorder.

Keywords:
Calidad de vidaCushingCushing's diseaseHipercortisolemiaHypercortisolismQuality of life

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Last Updated: May 7, 2026

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Area of Science:

  • Endocrinology
  • Internal Medicine

Background:

  • Cushing's disease is a rare endocrine disorder caused by excess cortisol.
  • Understanding recent advancements is crucial for patient management.

Purpose of the Study:

  • To review and synthesize literature on Cushing's disease published between October 2011 and September 2012.
  • To analyze key findings from major scientific meetings.

Main Methods:

  • Literature search and selection based on predefined author criteria.
  • Classification of articles into five thematic groups: quality of life, clinical features/pathophysiology, comorbidities, diagnosis, and treatment.

Main Results:

  • The review covers diverse aspects of Cushing's disease, including patient-reported outcomes and disease perception.
  • Key findings on clinical manifestations, underlying pathophysiology, and associated health conditions are discussed.
  • Current diagnostic strategies and therapeutic interventions are analyzed based on recent publications.

Conclusions:

  • The study provides a comprehensive overview of the state of knowledge on Cushing's disease during the review period.
  • Highlights the importance of a multidisciplinary approach in managing Cushing's disease.
  • Identifies areas for future research and clinical focus.