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Related Experiment Video

Updated: May 7, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

Leptin-induced endothelial dysfunction is mediated by sympathetic nervous system activity.

Jintao Wang¹, Hui Wang, Wei Luo

¹Department of Internal Medicine, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI.

Journal of the American Heart Association

|September 18, 2013

Summary

Leptin, elevated in obesity, impairs blood vessel function by activating the sympathetic nervous system and increasing oxidative stress. This contributes to hypertension and vascular stiffness.

Keywords:

ganglionectomy hypertension nervous system obesity superoxide

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Area of Science:

Cardiovascular Physiology
Endocrinology
Vascular Biology

Background:

Leptin, an adipocyte hormone, is elevated in obesity and linked to increased vascular risk.
The precise mechanisms by which leptin influences vascular disease remain unclear.
Leptin has been observed to increase sympathetic nervous system activity.

Purpose of the Study:

To investigate the impact of leptin on endothelial function.
To determine the role of the local sympathetic nervous system in mediating leptin's vascular effects.

Main Methods:

Administration of recombinant leptin to C57BL6/J mice.
Mesenteric arteriole myography to assess vasorelaxation.
Evaluation of blood pressure responses to angiotensin II.
Sympathetic denervation of mesenteric vasculature and use of superoxide scavenger TEMPOL.

Main Results:

Leptin treatment impaired endothelium-dependent vasorelaxation.
Leptin augmented the blood pressure response to angiotensin II.
Sympathetic denervation and TEMPOL neutralized leptin's effects on vascular function and blood pressure.

Conclusions:

Leptin induces endothelial dysfunction and potentiates angiotensin II-mediated hypertension.
These effects are mediated by sympathetic nervous system activation and superoxide production.
Leptin's actions may contribute to obesity-associated vascular stiffness and hypertension.