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Related Experiment Video

Updated: May 7, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Necrotizing enterocolitis: have we made any progress in reducing the risk?

Leslie A Parker1

  • 1College of Nursing, University of Florida, Gainesville.

Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses
|September 18, 2013
PubMed
Summary

Necrotizing enterocolitis (NEC) is a severe intestinal disease in premature infants. Research is exploring new strategies to reduce NEC incidence and improve outcomes for vulnerable newborns in the neonatal intensive care unit (NICU).

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Last Updated: May 7, 2026

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Published on: February 15, 2018

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Critical Care

Background:

  • Necrotizing enterocolitis (NEC) is a devastating intestinal disease impacting premature infants, particularly in the neonatal intensive care unit (NICU).
  • Limited understanding of NEC pathophysiology has hindered progress in reducing its incidence and severity.
  • Increasing survival rates of extremely premature infants are expected to raise NEC diagnoses.

Purpose of the Study:

  • To review the current understanding of NEC pathophysiology and causes.
  • To discuss investigated strategies for NEC risk reduction.
  • To highlight the urgent need for effective interventions against NEC-related morbidity and mortality.

Main Methods:

  • Literature review of NEC pathophysiology.
  • Analysis of research on NEC risk reduction strategies.
  • Discussion of clinical implications for neonatal care.

Main Results:

  • Decades of research have not significantly reduced NEC risk or improved prognosis.
  • Advancements in understanding NEC have led to the investigation of several risk-reduction strategies.
  • Effective strategies are crucial to mitigate NEC-related complications.

Conclusions:

  • Further research into NEC pathophysiology is essential.
  • Investigated risk-reduction strategies show promise for improving outcomes in premature infants.
  • Developing and implementing effective NEC prevention and management is a critical goal in neonatal medicine.