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Paget's disease of bone.

R L Merkow1, J M Lane

  • 1University of Minnesota Medical School, Minneapolis.

The Orthopedic Clinics of North America
|January 1, 1990
PubMed
Summary

Paget's disease of bone involves abnormal bone remodeling with increased resorption and formation. Treatment aims to control disease activity and improve symptoms, with rare tumor development.

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Area of Science:

  • Bone biology
  • Pathology
  • Endocrinology

Background:

  • Paget's disease of bone is a chronic disorder characterized by disordered bone remodeling.
  • It involves excessive osteoclastic resorption followed by compensatory osteoblastic bone formation.
  • The etiology remains largely unknown, though viral factors are suspected.

Purpose of the Study:

  • To provide a comprehensive overview of Paget's disease of bone.
  • To discuss its pathophysiology, clinical presentation, and common sites of involvement.
  • To outline current therapeutic strategies and their aims.

Main Methods:

  • Review of existing literature on Paget's disease of bone.
  • Analysis of clinical and radiographic features.
  • Evaluation of therapeutic agents and their mechanisms.

Main Results:

  • Paget's disease typically affects the spine, femora, cranium, pelvis, and sternum.
  • Common symptoms include pain, skeletal deformity, and altered skin temperature.
  • Pathologic fractures are a frequent complication, particularly in lower extremity long bones.

Conclusions:

  • Current treatments, including calcitonins and diphosphonates, aim to manage disease activity and symptoms.
  • Early diagnosis is crucial for effective palliation.
  • While rare, tumors can occur, highlighting the importance of vigilant monitoring.

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