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Related Experiment Video

Updated: Mar 15, 2026

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing
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Macroglossia in amyotrophic lateral sclerosis.

Heather R McKee1, Edward Escott, Douglas Damm

  • 1Department of Neurology, University of Kentucky, Lexington.

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|September 18, 2013
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Summary
This summary is machine-generated.

This study reports on two rare cases of macroglossia (tongue enlargement) in patients with amyotrophic lateral sclerosis (ALS). Researchers propose a potential mechanism for this unusual ALS complication.

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Area of Science:

  • Neurology
  • Pathology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons.
  • Macroglossia, or tongue enlargement, is not a commonly recognized symptom of ALS.

Observation:

  • Two patients with ALS developed macroglossia after experiencing progressive weakness, dysarthria, dysphagia, and neck extensor weakness.
  • Imaging revealed tongue protrusion with edema, while biopsy showed fatty replacement and muscle degeneration.

Findings:

  • This is the first reported association between macroglossia and ALS.
  • The findings suggest macroglossia may be an extremely rare complication of ALS.

Implications:

  • This study highlights a previously undocumented clinical manifestation in ALS.
  • Further research is needed to understand the pathophysiology linking ALS and macroglossia.