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The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
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FAAH selectively influences placebo effects.

M Peciña1, M Martínez-Jauand2, C Hodgkinson3

  • 1Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

Molecular Psychiatry
|September 18, 2013
PubMed
Summary
This summary is machine-generated.

A common gene variant impacts the cannabinoid system, influencing placebo effects. Individuals with this variant experience enhanced placebo analgesia and positive mood, linked to greater opioid neurotransmission.

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Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Endogenous opioid and cannabinoid systems interact to regulate pain and reward.
  • Fatty acid amide hydrolase (FAAH) degrades endocannabinoids, playing a key role in the cannabinoid system.
  • Genetic variations in FAAH can affect endocannabinoid levels and system function.

Purpose of the Study:

  • To investigate the role of the FAAH Pro129Thr genetic variant on human responses to pain and placebo.
  • To examine the impact of this variant on psychophysical and neurotransmitter (dopaminergic, opioid) responses.
  • To understand the interaction between cannabinoid and opioid systems in placebo analgesia.

Main Methods:

  • Study participants genotyped for the FAAH Pro129Thr variant.
  • Assessment of pain perception and affective states.
  • Measurement of placebo-induced changes in neurotransmission (micro-opioid and dopaminergic).

Main Results:

  • FAAH Pro129/Pro129 homozygotes reported significantly higher placebo analgesia.
  • These individuals also experienced more positive affective states post-placebo.
  • Greater placebo-induced micro-opioid, but not dopaminergic, neurotransmission enhancements were observed in homozygotes.

Conclusions:

  • A common FAAH genetic variation influences placebo analgesia and affective responses.
  • This variant highlights the synergistic roles of cannabinoid and opioid systems in placebo effects.
  • The FAAH Pro129Thr variant serves as a valuable tool for probing placebo mechanisms.