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Updated: May 7, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Therapeutic modalities in systemic lupus erythematosus
Naveen K Tyagi1, Robert G Lahita
1Department of Internal Medicine, Newark Beth Israel Medical Center, Newark, New Jersey, United States of America.
Saudi Medical Journal
|September 18, 2013
Summary
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. This review covers SLE pathogenesis, current treatments, and emerging biological therapies targeting immune cells and pathways for better disease management.
Area of Science:
- Immunology
- Rheumatology
- Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder.
- Pathogenesis involves genetic factors, immune cell dysregulation, and autoantibodies.
- Traditional treatments include NSAIDs, antimalarials, corticosteroids, and immunosuppressants.
Purpose of the Study:
- To review the pathogenesis of SLE.
- To discuss current and novel biological treatments for SLE.
- To explore therapies for specific manifestations like neuropsychiatric and cutaneous lupus.
Main Methods:
- Literature review of SLE pathogenesis.
- Analysis of current therapeutic modalities.
- Examination of emerging biological and targeted therapies.
Main Results:
- SLE pathogenesis is complex, involving multiple immune system components.
- Biological agents targeting B cells, cytokines, and regulatory T cells represent a new treatment paradigm.
- Novel therapies are being developed for specific SLE manifestations.
Conclusions:
- Understanding SLE pathogenesis is crucial for developing targeted therapies.
- The shift towards immune-targeted therapies offers new hope for SLE patients.
- Future research focuses on personalized treatments for diverse SLE manifestations.
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