[Translational research in regenerative medicine: an example of bone marrow transplantation]

Science provides diagnostic and therapeutic methods that subsequently need to be introduced to routine clinical practice in ordered way. Translational research allows for adaptation of methods developed on experimental animals to the requirements of man. This process requires on one hand consideration of biological differences between model organisms (in case of bone marrow transplantation mainly mouse and dog) and man and consideration of differences in size (usually upscaling of procedures). Procedures that have been elaborated during translation of methods of transplantation of hematopoietic cells elaborated on experimental animals to clinical situations could be successfully used during introduction to the clinic of other types of cellular therapies.