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Association of adipokines with obesity in children and adolescents

Anila Jaleel1, Bilal Aheed, Shahila Jaleel

  • 1Department of Biochemistry, Ziauddin University, 4/B, Shahrah-e-Ghalib, Block 6, Clifton, Karachi 75600, Pakistan. aneelajaleel@hotmail.com.

Biomarkers in Medicine
|September 19, 2013
PubMed

Insights

Childhood obesity is linked to altered adipokine levels. Adiponectin and visfatin show significant associations with obesity in children and adolescents.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Obesity Research

Background:

  • Childhood obesity is a global health crisis.
  • Obesity increases the risk of chronic diseases like hypertension and diabetes.
  • Adipokines, including resistin, visfatin, leptin, and adiponectin, are key players in obesity.

Purpose of the Study:

  • To investigate the association between serum adipokine levels and childhood obesity.
  • To compare adipokine profiles in obese versus non-obese children.

Main Methods:

  • Studied 90 children (ages 5-18), including 60 controls and 30 obese subjects.
  • Measured serum visfatin, TNF-α, resistin, insulin, and adiponectin using ELISA.
  • Calculated insulin resistance using the Homeostasis Model Assessment (HOMA-IR).

Main Results:

  • Obese children had significantly higher HOMA-IR, TNF-α, and visfatin levels compared to controls.
  • Obese children exhibited significantly lower serum adiponectin levels than controls.
  • Adiponectin and visfatin levels were found to be significantly associated with obesity via logistic regression.

Conclusions:

  • Circulating adipokine levels are altered in childhood obesity.
  • Adiponectin and visfatin are significantly associated with obesity in pediatric populations.
Abstract

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