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Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

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Published on: September 26, 2019

Prospective memory in Parkinson's disease: a meta-analysis.

Siddharth Ramanan¹, Devvarta Kumar

¹1 Department of Neurology, Manipal Hospitals, Bangalore, Karnataka, India.

Journal of the International Neuropsychological Society : JINS

|September 19, 2013

Summary

Prospective memory (PM), the ability to remember future intentions, is impaired in Parkinson's disease (PD). Both time-based and event-based PM are affected, with time-based PM showing a slightly greater deficit.

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Area of Science:

Cognitive Neuroscience
Neurology
Psychology

Background:

Prospective memory (PM) is crucial for daily functioning, involving remembering to perform intended actions at future times.
Parkinson's disease (PD) is associated with significant cognitive impairments, including deficits in prospective memory.
Failures in PM can lead to serious consequences, impacting daily life and safety.

Purpose of the Study:

To conduct a meta-analytic review of prospective memory deficits in individuals with Parkinson's disease.
To quantify the extent of impairment in both time-based and event-based prospective memory in PD.
To explore potential underlying mechanisms contributing to PM deficits in PD.

Main Methods:

A meta-analysis was performed, synthesizing data from nine independent studies examining prospective memory in Parkinson's disease.
Effect sizes (Hedges' g) were calculated to compare PM performance between PD patients and control groups.
Analyses focused on differentiating impairments in time-based versus event-based prospective memory.

Main Results:

Results indicated a significant impairment in prospective memory in Parkinson's disease patients compared to controls.
Both time-based PM (Hedges' g = -0.71) and event-based PM (Hedges' g = -0.55) were similarly compromised, with a slightly larger deficit observed for time-based PM.
The findings suggest that the primary issue in PD-related PM deficits may stem from difficulties in self-initiated retrieval of intentions.

Conclusions:

Prospective memory is demonstrably impaired in Parkinson's disease, affecting both time- and event-based tasks.
The deficit is likely related to impaired self-initiated retrieval processes rather than forgetting the intention's content.
Intervening task complexity and executive function deficits may mediate prospective memory impairments in Parkinson's disease.