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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: May 7, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Correlation between Th17 cells and tumor microenvironment.

Wenhui Qi1, Xiaojuan Huang, Junyan Wang

  • 1Department of Histology and Embryology, Tianjin Medical University, Tianjin, China.

Cellular Immunology
|September 19, 2013
PubMed
Summary
This summary is machine-generated.

T helper 17 (Th17) cells are crucial in human diseases like autoimmune conditions and cancer. This review synthesizes molecular pathways, migration, and contradictory roles in tumorigenesis to guide Th17-targeted cancer therapies.

Keywords:
IL-17Th17 cellsTumor microenvironment

More Related Videos

Isolation and Th17 Differentiation of Na&iuml;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Related Experiment Videos

Last Updated: May 7, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Isolation and Th17 Differentiation of Na&iuml;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • T helper 17 (Th17) cells, identified in 2005, are implicated in autoimmune diseases, inflammation, allergy, and cancer.
  • Understanding Th17 cell differentiation and function is critical for developing targeted therapies.

Purpose of the Study:

  • To review molecular interactions, signaling pathways, and migration mechanisms driving Th17 cell differentiation and function in the tumor microenvironment.
  • To synthesize current, often contradictory, findings on the role of Th17 cells in tumorigenesis.
  • To provide guidance for Th17-targeted therapies in cancer treatment.

Main Methods:

  • Literature review focusing on human studies.
  • Analysis of molecular interactions including cytokines (IL-1β, IL-6, IL-23, IL-21, TGF-β).
  • Examination of the STAT3→RORγt signaling pathway and CCR6/CCL20-mediated migration.

Main Results:

  • Key molecular players (IL-1β, IL-6, IL-23, IL-21, TGF-β) and the STAT3→RORγt pathway are essential for Th17 differentiation and function.
  • CCR6/CCL20 signaling facilitates Th17 cell migration into tumor sites.
  • The role of Th17 cells in tumorigenesis presents conflicting evidence, suggesting context-dependent functions.

Conclusions:

  • Th17 cells possess complex roles in tumor microenvironments, influenced by specific molecular interactions and signaling pathways.
  • Contradictory findings necessitate careful consideration for effective Th17-targeted cancer therapies.
  • Further research is needed to elucidate the precise functions of Th17 cells in different cancer types to optimize therapeutic strategies.