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A polyvalent aptamer system for targeted drug delivery.

Zhiqing Zhang1, M Monsur Ali, Mark A Eckert

  • 1State Key Laboratory of Heavy Oil Processing, College of Science, China University of Petroleum, Qingdao 266580, People's Republic of China; Department of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center and Chao Family Comprehensive Cancer Center, University of California, Irvine, 845 Health Sciences Road, Irvine, CA 92697, USA; Department of Biomedical Engineering, and Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 845 Health Sciences Road, Irvine, CA 92697, USA.

Biomaterials
|September 19, 2013
PubMed
Summary

New polyvalent aptamer-drug conjugates show enhanced efficacy for leukemia treatment. This novel approach improves cancer cell targeting and internalization, potentially reducing chemotherapy side effects.

Keywords:
AptamerCancerDrug deliveryLeukemiaMultivalencyRolling circle amplification

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