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Assessment of asthma control: the SERENA study
Antonio Corrado1, Teresa Renda, Guido Polese
1Respiratory Intensive Care Unit and Thoracic Physiopathology, University and General Hospital Careggi, Firenze, Italy.
Respiratory Medicine
|September 19, 2013
Summary
Asthma control remains a challenge, with over 90% of patients on inhaled corticosteroids and long-acting beta-agonists experiencing partly or uncontrolled disease. Female sex, reduced lung function, and exacerbations are key risk factors for uncontrolled asthma.
Area of Science:
- Pulmonology
- Clinical Practice Research
- Asthma Management
Background:
- Asthma control is a primary therapeutic goal, yet many patients experience uncontrolled symptoms.
- Real-world data is crucial for understanding asthma control levels in routine clinical settings.
Purpose of the Study:
- To evaluate asthma control using the Asthma Control Test (ACT) in patients treated with inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA).
- To identify risk factors associated with uncontrolled asthma in this patient population.
Main Methods:
- The SERENA study was a multi-centre, observational, cross-sectional study in 16 Italian Pulmonary Units.
- 396 adult asthmatic outpatients on medium-high dose ICS/LABA were enrolled and categorized by ACT scores.
- Asthma control was defined as ACT score ≥25 (controlled), 20-24 (partly controlled), and <20 (uncontrolled).
Main Results:
- Only 9.1% of patients achieved controlled asthma; 39.6% were partly controlled, and 51.3% were uncontrolled.
- Uncontrolled asthma was more prevalent in females (63.1%) and associated with lower FEV1% predicted.
- Higher rates of exacerbations, unscheduled visits, and hospital admissions were observed in partly controlled and uncontrolled groups.
Conclusions:
- A significant majority of patients treated with ICS/LABA have suboptimal asthma control in real-life practice.
- Periodic assessment of asthma control and exacerbation history is vital for effective management.
- Female sex, reduced FEV1, and exacerbations are significant independent predictors of uncontrolled asthma.
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