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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
Preterm birth, respiratory failure and BPD: which neonatal management?
Francesca Castoldi1, Gianluca Lista, Fabio Scopesi
1Neonatal Pulmonology Study Group, Italian Society of Neonatology, Italy; NICU-V. Buzzi-Ospedale dei Bambini, ICP, Milan, Italy.
Preventing preterm birth is key to reducing infant mortality and long-term morbidity like bronchopulmonary dysplasia (BPD). If premature delivery occurs, immediate respiratory support and tailored NICU care are crucial for high-risk infants.
Area of Science:
- Neonatal Medicine
- Perinatology
- Respiratory Medicine
Background:
- Preterm birth significantly contributes to global perinatal mortality and long-term morbidity, particularly bronchopulmonary dysplasia (BPD).
- Premature infants often struggle with the transition to extrauterine life, failing to establish functional residual capacity (FRC) and requiring respiratory support.
- Bronchopulmonary dysplasia (BPD) is a major concern in the long-term health of premature infants.
Purpose of the Study:
- To emphasize the critical importance of preventing preterm birth as the primary strategy against BPD.
- To outline the essential management steps for high-risk infants when preterm birth is unavoidable.
- To highlight the need for continuous, tailored care from the delivery room through the NICU to mitigate BPD risks.
Main Methods:
- Review of current literature and clinical guidelines on preterm birth and BPD prevention.
- Analysis of the physiological challenges faced by preterm infants during respiratory transition.
- Emphasis on proactive risk factor management in neonatal intensive care units (NICUs).
Main Results:
- Avoiding preterm birth is the most effective method to prevent BPD.
- Failure to establish adequate FRC is a common issue in premature infants requiring respiratory support.
- Targeted management strategies initiated in the delivery room and continued in the NICU are vital for high-risk infants.
Conclusions:
- The primary goal in preventing BPD is to prevent preterm birth.
- For infants born prematurely, immediate and specialized respiratory management is essential.
- A comprehensive, tailored approach to care in the NICU is crucial for minimizing the incidence and severity of BPD in high-risk neonates.
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