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Published on: January 22, 2018
Factors affecting 18F-FDG uptake by metastatic lymph nodes in gastric cancer
Young Hwan Kim1, Joon Young Choi, In-Gu Do
1*From the Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; †Department of Nuclear Medicine, Hanyang University Guri Hospital, Hanyang University School of Medicine, Guri; and Departments of ‡Pathology and §Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.†Department of Nuclear Medicine, Hanyang University Guri Hospital, Hanyang University School of Medicine, Guri; and Departments of ‡Pathology and § Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Objective:
We assessed factors affecting fluorine F 18 fluorodeoxyglucose (F-FDG) uptake of metastatic lymph nodes (LNs) in advanced gastric cancer (AGC) due to low F-FDG uptake of metastatic LNs in gastric cancer.
Methods:
Retrospective analyses were performed on 31 patients with AGCs who underwent preoperative F-FDG positron emission tomography (PET) and subsequent gastrectomy. Metastatic LNs were compared with primary tumors (on a one-to-one basis) with respect to maximum standardized uptake values, glucose transporter type 1 (GLUT-1) expression, proliferation indices (using Ki-67), microvessel density, and lymphatic vessel density.
Results:
Maximum standardized uptake values of metastatic LNs were significantly correlated with % GLUT-1 expression (ρ = 0.80, P < 0.0001) and Ki-67 labeling index (ρ = 0.57, P = 0.001) in LNs. These uptake values were also significantly correlated with SUVs (ρ = 0.54; P = 0.002), % GLUT-1 expression (ρ = 0.71, P < 0.0001), and Ki-67 labeling index (ρ = 0.43, P = 0.019) in primary tumors. In multiple regression analysis, only % GLUT-1 expression in primary tumors and metastatic LNs were significant factors in predicting maximum standardized uptake value of metastatic LNs.
Conclusions:
In AGCs, GLUT-1 expression and Ki-67 labeling index are important factors in predicting F-FDG uptake by metastatic LNs.
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