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Published on: August 28, 2020
Subicular activation preceding hippocampal ripples in vitro
Hiroaki Norimoto1, Nobuyoshi Matsumoto, Takeyuki Miyawaki
11] Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan [2].
Scientific Reports
|September 19, 2013
Summary
Sharp wave-ripples (SW-Rs) are crucial for memory consolidation. New research shows subicular neurons activate before SW-Rs, suggesting entorhinal input triggers these events and the subiculum actively modifies related neural information.
Area of Science:
- Neuroscience
- Memory Consolidation Research
Background:
- Sharp wave-ripple complexes (SW-Rs) are high-frequency oscillations in the hippocampus, believed to be vital for memory consolidation.
- The initiation and propagation pathways of SW-Rs, particularly their origin and subicular role, remain incompletely understood.
Purpose of the Study:
- To investigate the initiation mechanisms and propagation dynamics of hippocampal Sharp wave-ripple complexes (SW-Rs).
- To elucidate the role of the subiculum in the generation and modulation of SW-Rs.
Main Methods:
- Functional multineuronal calcium imaging was employed to observe SW-R-related neuronal activity in the subiculum at single-cell resolution.
- Neuronal activity preceding SW-Rs was monitored, and the effect of CA1-to-subiculum projection lesions was assessed.
Main Results:
- A subset of subicular neurons exhibited pre-Sharp wave-ripple (SW-R) activity, preceding the complex oscillations.
- This pre-SW-R activity persisted after CA1 lesions, indicating an origin from entorhinal inputs.
- The subiculum demonstrated an active role, rather than passive transmission, in modifying neural information during SW-Rs.
Conclusions:
- Sharp wave-ripples (SW-Rs) are likely triggered by inputs from the entorhinal cortex to the hippocampus (CA3/CA1 regions).
- The subiculum actively participates in modulating neural information associated with SW-Rs, suggesting a more dynamic role than previously assumed.
