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Updated: May 7, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents
Sarina J Dorazio1, Abiola O Olatunde, Joseph A Spernyak
1Department of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA. jmorrow@buffalo.edu.
Abstract:
The first examples of air-stable Co(II) paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.
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