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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
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Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

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An Ex vivo Culture System to Study Thyroid Development
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Published on: June 6, 2014

Establishing trimester-specific maternal thyroid function reference intervals.

Azy S Khalid1, Zbigniew Marchocki, Kevin Hayes

  • 1Anu Research Centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Cork, Republic of Ireland.

Annals of Clinical Biochemistry
|September 19, 2013
PubMed
Summary
This summary is machine-generated.

This study established trimester-specific thyroid function reference intervals for pregnant women, aiding in the management of thyroid disorders during pregnancy. These new ranges improve clinical practice for expectant mothers.

Keywords:
Thyroid hormonesanalytesclinical studiesimmunoassaypregnancy

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Area of Science:

  • Endocrinology
  • Reproductive Health
  • Clinical Chemistry

Background:

  • Thyroid disorders are prevalent in women of childbearing age, posing risks to pregnancy outcomes.
  • Managing thyroid conditions during pregnancy is complex due to physiological changes and a lack of specific reference ranges.
  • Thyroid autoimmunity in euthyroid pregnant women requires further investigation.

Purpose of the Study:

  • To establish trimester-specific thyroid function reference intervals throughout pregnancy.
  • To determine the prevalence of thyroid autoimmunity in euthyroid pregnant women.
  • To provide updated reference ranges for clinical use in managing thyroid disorders during gestation.

Main Methods:

  • Prospective, cross-sectional study involving pregnant women at a tertiary referral maternity hospital.
  • Exclusion of patients with pre-existing thyroid disorders, autoimmune diseases, or pregnancy complications.
  • Analysis of thyroid function tests (TFTs) using electrochemiluminescent immunoassay to calculate trimester-specific reference ranges.

Main Results:

  • Included 351 pregnant women with a median age of 30.
  • Observed a slight increase in median thyroid-stimulating hormone (TSH) concentrations throughout gestation.
  • Noted a decrease in median free thyroxine (T4) and triiodothyronine (T3) levels as pregnancy progressed.

Conclusions:

  • Successfully established pregnancy-specific thyroid function reference intervals.
  • These intervals are suitable for application in clinical practice for pregnant populations.
  • The study provides a foundation for improved thyroid disorder management during pregnancy.