Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 7, 2026

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
08:31

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

A peptide probe for targeted brown adipose tissue imaging.

Ali Azhdarinia1, Alexes C Daquinag, Chieh Tseng

  • 11] Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA [2].

Nature Communications
|September 19, 2013
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fibulin-4 expressed in metastatic breast cancer is a target of peptide-based imaging probes and experimental therapeutics.

Molecular therapy. Oncology·2026
Same author

Investigating machine learning algorithms to classify label-free images of pancreatic neuroendocrine neoplasms.

Biophotonics discovery·2026
Same author

Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction.

Aging cell·2026
Same author

Nanoparticle encapsulation enhances spatial distribution of Panobinostat to treat metastatic medulloblastoma via the intrathecal route.

bioRxiv : the preprint server for biology·2026
Same author

γδ T cells at the interface of innate and adaptive immunity in cancer.

Journal for immunotherapy of cancer·2026
Same author

Adipose Stromal Cell-Derived Cancer-Associated Fibroblasts Promote Pancreatic Adenocarcinoma Progression Through SFRP4 Signaling.

Cancers·2026

Researchers identified a novel peptide probe (CPATAERPC) that selectively targets brown adipose tissue vasculature. This discovery aids in visualizing and understanding brown adipose tissue distribution and function in vivo.

Area of Science:

  • Adipose tissue biology
  • Molecular imaging
  • Endocrinology

Background:

  • Brown adipose tissue (BAT) plays a crucial role in thermogenic energy dissipation in adult humans, holding significant clinical importance.
  • Current methods for detecting and analyzing BAT abundance and localization are limited, posing challenges for research.
  • Developing new tools is essential for advancing the study of BAT's role in metabolism and energy balance.

Purpose of the Study:

  • To identify a molecular probe for selective detection of brown adipose tissue.
  • To characterize the binding properties and localization of a novel peptide targeting BAT vasculature.
  • To evaluate the utility of this probe for in vivo imaging of BAT depots.

Main Methods:

  • Screening of a combinatorial peptide library in mice.

More Related Videos

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
10:30

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Published on: April 1, 2019

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

Related Experiment Videos

Last Updated: May 7, 2026

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
08:31

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
10:30

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Published on: April 1, 2019

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

  • Characterization of a peptide (CPATAERPC) for selective binding to the vascular endothelium of BAT.
  • Assessment of probe localization in different adipose tissue depots and under varying physiological conditions.
  • Whole-body near-infrared fluorescence imaging for BAT depot identification.

    • Main Results:

    • A peptide (CPATAERPC) was identified that selectively binds to the vascular endothelium of brown adipose tissue in mice.
    • The peptide also recognizes the vasculature of brown adipose tissue-like depots in subcutaneous white adipose tissue.
    • CPATAERPC localizes to brown adipose tissue independently of sympathetic nervous system stimulation.
    • The probe enabled successful identification of brown adipose tissue depots via whole-body near-infrared fluorescence imaging.

    Conclusions:

    • The CPATAERPC peptide serves as a valuable molecular probe for targeting brown adipose tissue vasculature.
    • This probe facilitates non-invasive imaging and characterization of brown adipose tissue distribution in vivo.
    • The findings offer a new tool for studying the physiology and therapeutic potential of brown adipose tissue.