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Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22)
Ryan C Johnson1, Natasha M Savage, Tsoyu Chiang
1Dept of Pathology, Stanford University School of Medicine, 300 Pasteur Dr, MC 5324, Stanford, CA 94086;
Objectives:
To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22).
Methods:
We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction.
Results:
Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia.
Conclusions:
We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.
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