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Repeated erythromycin/codeine-induced psychotic mania
Mirko Manchia1, Martin Alda, Cynthia V Calkin
1Departments of *Psychiatry, and †Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
Clinical Neuropharmacology
|September 19, 2013
Summary
Commonly prescribed medications like erythromycin and acetaminophen with codeine can cause iatrogenic mania. Clinicians should monitor for psychiatric side effects, especially when these drugs are used together.
Area of Science:
- Psychiatry
- Pharmacology
- Neurology
Background:
- Mania is typically linked to bipolar disorder but can be iatrogenically induced by medications.
- Certain drugs, including antibiotics and corticosteroids, are known to precipitate manic symptoms.
Observation:
- A case study details a young man experiencing psychotic mania after receiving erythromycin and acetaminophen with codeine.
- These manic episodes resolved quickly after drug administration on two separate occasions.
Findings:
- Rare adverse events of psychotic mania were reported with erythromycin and acetaminophen with codeine.
- The study highlights the potential for these common medications to cause psychiatric disturbances.
Implications:
- Clinicians must consider iatrogenic causes of mania, particularly with combined drug use.
- Awareness of these potential side effects is crucial for patient safety and effective treatment.
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