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Impact of cardiovascular comorbidity on ovarian cancer mortality

Eileen H Shinn1, Daniel J Lenihan, Diana L Urbauer

  • 1Authors' Affiliations: University of Texas M.D. Anderson Cancer Center, Houston, Texas; Vanderbilt University Medical Center, Nashville, Tennessee; IDDI Corp., Houston, Texas; University of Texas Medical Branch at Galveston, Galveston, Texas; Moffitt Cancer Center, Tampa, Florida; University of Arkansas for Medical Sciences, Little Rock, Arkansas; St. Luke's Roosevelt Hospital Center, New York, New York; and University of Iowa, Iowa City, Iowa.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|September 19, 2013
PubMed

Insights

Cardiovascular issues like venous thromboembolism and pulmonary hypertension, along with high heart rate, are linked to poorer ovarian cancer survival. Managing these conditions may improve outcomes for ovarian cancer patients.

Area of Science:

  • Oncology
  • Cardiology
  • Epidemiology

Background:

  • Ovarian cancer survival remains poor despite treatment advances.
  • The impact of cardiovascular comorbidity and chronic stress on ovarian cancer outcomes is not well understood.
  • This study investigates the association between cardiovascular disease, stress markers, and survival in ovarian cancer patients.

Purpose of the Study:

  • To determine if cardiovascular disease and stress-associated markers impact ovarian cancer survival.
  • To identify specific cardiovascular comorbidities that affect prognosis in epithelial ovarian cancer.
  • To explore the relationship between baseline heart rate and ovarian cancer patient survival.

Main Methods:

  • Retrospective cohort study of 271 patients with newly diagnosed epithelial ovarian cancer.
  • Data collected prospectively from August 2003 to March 2008.
  • Analysis compared tumor characteristics, demographics, cardiovascular comorbidities, and survival outcomes.

Main Results:

  • Venous thromboembolism (VTE) and pulmonary hypertension were significantly associated with shorter survival.
  • High tumor grade, suboptimal cytoreduction, and elevated baseline heart rate also correlated with decreased survival.
  • Multivariate analysis identified VTE and pulmonary hypertension as independent predictors of reduced survival.

Conclusions:

  • Management of cardiovascular comorbidities such as tachycardia, VTE, and pulmonary hypertension may improve ovarian cancer survival.
  • Baseline heart rate, VTE, and pulmonary hypertension are significant predictors of survival in women with ovarian cancer.
  • Optimal treatment of these cardiovascular conditions alongside cancer therapy is crucial for enhancing patient prognosis.
Abstract

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