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Related Concept Videos

Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: May 7, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

Osseointegration in the elderly.

G Piarulli1, A Rossi, G Zatti

  • 1Azienda Ospedaliera San Gerardo, Università degli Studi di Milano-Bicocca, Via Pergolesi, 33, 20900, Monza, Italy, giorgio.piarulli@gmail.com.

Aging Clinical and Experimental Research
|September 19, 2013
PubMed
Summary
This summary is machine-generated.

Achieving osseointegration for cementless hip implants is challenging in patients with osteoporosis. Bone quality changes in osteoporosis compromise implant stability and the bone

Related Experiment Videos

Last Updated: May 7, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

Area of Science:

  • Orthopedic surgery
  • Biomaterials science
  • Bone biology

Background:

  • Osseointegration is crucial for cementless femoral fixation in total hip arthroplasty.
  • Implant stability and long-term success depend on mechanical and biological factors.
  • Osteoporosis negatively impacts bone morphology and biology in the proximal femur.

Purpose of the Study:

  • To investigate the challenges of osseointegration in the context of osteoporosis for cementless hip arthroplasty.
  • To understand how osteoporosis affects the bone-implant interface.

Main Methods:

  • Review of existing literature on osseointegration, cementless hip arthroplasty, and osteoporosis.
  • Analysis of morphological and biological changes in osteoporotic bone relevant to implant fixation.

Main Results:

  • Osteoporosis induces alterations in proximal femur morphology and biology.
  • These changes adversely affect the mechanical stability of femoral implants.
  • The biological response of osteoporotic bone is compromised, hindering osseointegration.

Conclusions:

  • Achieving successful osseointegration for cementless femoral fixation is significantly more challenging in osteoporotic patients.
  • Addressing the effects of osteoporosis on bone quality is essential for improving outcomes in total hip arthroplasty.