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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

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Related Experiment Video

Updated: May 7, 2026

Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

Ankle fractures in elderly patients.

Sandro Giannini1, Eugenio Chiarello, Valentina Persiani

  • 1Orthopaedic and Traumatologic Clinic, University of Bologna, Rizzoli Orthopaedic Institute, Bologna, BO, Italy.

Aging Clinical and Experimental Research
|September 19, 2013
PubMed
Summary

Ankle fractures (AFs) in the elderly are increasing and predict other osteoporotic fractures. Low-trauma AFs in postmenopausal women suggest underlying osteoporosis, warranting similar consideration to other osteoporotic fractures.

Related Experiment Videos

Last Updated: May 7, 2026

Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

Area of Science:

  • Geriatric Medicine
  • Orthopedic Surgery
  • Osteoporosis Research

Background:

  • Rising incidence of ankle fractures (AFs) in the elderly population due to increased life expectancy.
  • AFs serve as a predictor for subsequent osteoporotic fractures at other skeletal sites, rather than being solely linked to osteoporosis.
  • In women, AFs correlate with weight and Body Mass Index (BMI).

Purpose of the Study:

  • To highlight the significance of ankle fractures in the elderly.
  • To discuss the categorization and treatment options for ankle fractures.
  • To propose considering low-trauma AFs in postmenopausal women as indicative of osteoporosis.

Main Methods:

  • Review of current literature on ankle fractures in the elderly.
  • Analysis of the relationship between AFs, osteoporosis, and patient comorbidities.
  • Consideration of bone microarchitecture and stiffness data in postmenopausal women.

Main Results:

  • Ankle fractures are increasingly common in the elderly and predict future osteoporotic fractures.
  • Treatment decisions for AFs require consideration of fracture type and patient comorbidity.
  • Postmenopausal women with AFs exhibit compromised bone microarchitecture and reduced stiffness.

Conclusions:

  • Low-trauma ankle fractures in postmenopausal women should be evaluated similarly to other osteoporotic fractures due to evidence of altered bone quality.
  • Comprehensive assessment including local and general comorbidity is crucial for guiding AF treatment.
  • Further research into the underlying causes and optimal management of AFs in the elderly is warranted.