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[Tricyclic antidepressant plasma levels in depression: a practical guide]
R Vis1, J J M Hassink, C H Vinkers
1Klinische Farmacie, St. Antonius Ziekenhuis, Nieuwegein. r.vis@antoniusziekenhuis.nl
Background:
Plasma levels can be used to monitor the clinical efficacy of tricyclic antidepressants (TCAs). In practice, the interpretation of plasma levels can be problematical, for several reasons: varying time-intervals between ingestion and blood sampling, the number of times per day a particular antidepressant is administered, the presence of active metabolites and the use of slow-release substances.
Aim:
To present realistic recommendations regarding the interpretation of plasma levels of TCA in clinical practice.
Method:
We studied the relevant literature.
Conclusion:
On the basis of the literature we make the following recommendations:
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