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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Updated: May 7, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Histoplasmosis after solid organ transplant.

Maha Assi1, Stanley Martin, L Joseph Wheat

  • 1Department of Internal Medicine, University of Kansas School of Medicine, Wichita.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|September 19, 2013
PubMed
Summary
This summary is machine-generated.

Histoplasmosis is a significant risk after solid organ transplant (SOT), particularly in the first year. Early diagnosis and treatment with amphotericin followed by azoles are crucial for survival and preventing relapse.

Keywords:
fungal infectionhistoplasmosissolid organ transplant

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Area of Science:

  • Infectious Diseases
  • Transplantation Medicine
  • Mycology

Background:

  • Histoplasmosis is a serious fungal infection that can occur after solid organ transplant (SOT).
  • Understanding risk factors, diagnosis, and outcomes is crucial for managing this complication.

Purpose of the Study:

  • To analyze a large cohort of histoplasmosis cases in SOT recipients.
  • To identify risk factors, diagnostic methods, treatment strategies, and outcomes.

Main Methods:

  • Retrospective analysis of 152 histoplasmosis cases in SOT recipients across 24 institutions (2003-2010).
  • Data collection included demographics, clinical presentation, laboratory findings, and treatment details.

Main Results:

  • Kidney transplant recipients were most commonly affected (51%).
  • The highest risk period was the first year post-transplant (34% of cases), though late cases occurred.
  • Urine Histoplasma antigen testing showed high sensitivity (93%).
  • Treatment involved initial amphotericin followed by azoles for 12 months.
  • Mortality was 10%, with older age and severe disease as risk factors.

Conclusions:

  • The first year post-SOT is the highest risk period for histoplasmosis.
  • Prompt treatment with amphotericin and azoles is generally successful, with low relapse rates.