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Updated: May 7, 2026

High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
Published on: March 10, 2023
A prototype direct-detection CCD for protein crystallography
Katherine S Green1, Doletha M E Szebenyi, Kasey Boggs
1Department of Physics, Cornell University, Ithaca, NY 14853, USA.
Abstract:
The fabrication and testing of a prototype deep-depletion direct-conversion X-ray CCD detector are described. The device is fabricated on 600 µm-thick high-resistivity silicon, with 24 × 24 µm pixels in a 4k × 4k pixel format. Calibration measurements and the results of initial protein crystallography experiments at the Cornell High Energy Synchrotron Source (CHESS) F1 beamline are described, as well as suggested improvements for future versions of the detector.
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