The relationship between life stress and depression in an endogenous sample
Related Experiment Video
Updated: Nov 6, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
1Psychology Service, Veterans Administration Medical Center West Los Angeles, CA 90073.
Abstract:
The role of stress was examined in a sample of 68 endogenously depressed patients. Antecedent and concurrent life events and long-term difficulties, operationalized by different subcategories and scoring options, were related to depression severity, treatment response versus nonresponse, and maintenance versus relapse. Results showed an association between initial depression and various categories of subjective stress; a reduction in subjective (but not objective) event-related stress coincident with remission; positive relationships between life events and response and maintenance and between difficulties and relapse; and a higher event profile among unipolar depressive patients. Results are discussed in terms of the positive prognostic value of reactivity in endogenous depression, as well as the interactive relationship between continuing depression and long-term difficulties.
Related Concept Videos
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
General State of Stress
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
Introduction to Stress and Lifestyle
Psychological Responses to Stress
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

