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Updated: May 7, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Ethyl 4-acetyl-5-anilino-3-methyl-thio-phene-2-carboxyl-ate
Yahia Nasser Mabkhot1, Fatima Alatibi, Assem Barakat
1Department of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia.
Abstract:
In the title compound, C16H17NO3S, a thio-phene derivative with amino phenyl, acetyl, methyl and ethyl carboxyl susbtituents attached to a central thio-phene ring, the phenyl and thio-phene rings form a dihedral angle of 36.92 (9) Å. The mol-ecular conformation is stabilized by an intra-molecular N-H⋯O hydrogen bond, which forms an S(6) ring motif.
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