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Updated: May 7, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
Published on: January 29, 2017
O-Benzoyl-naltrexone
Rui Yang1, Guo-Hai Wang, Xia-Li Liu
1Department of Pharmacology, Technical Center, Jiangsu Nhwa Pharma Corporation, Zhongshan Road No. 289, Xuzhou 221009, People's Republic of China.
Abstract:
In the title compound, C27H27NO5 (systematic name: 17-cyclopropylmethyl-14-hydroxy-6-oxo-4,5-epoxymorphin-an-6-yl benzoate), which is the benzoate ester of the opioid receptor antagonist naltrexone, the dihedral angle between the two phenyl rings is 77.1 (1)°. In the crystal, a weak aromatic C-H⋯Ocarbox-yl hydrogen bond involving the benzoate groups of adjacent mol-ecules gives rise to a chain extending along the a-axis direction. The known absolute configuration for the mol-ecule was inferred from a previous naltrexone structure.
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