Methyl 3-[(6-nitro-4-oxo-3-phenyl-3,4-di-hydro-quinazolin-2-yl)sulfan-yl]propano-ate
Ibrahim A Al-Suwaidan1, Alaa A-M Abdel-Aziz, Adel S El-Azab
1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Abstract:
In the title compound, C18H15N3O5S, the approximately planar quinazoline ring system [maximum deviation = 0.097 (3) Å] forms a dihedral angle of 76.53 (19)° with the phenyl ring. The terminal -C(=O)-O-C group is disordered over two sets of sites with a site-occupancy ratio of 0.811 (17):0.189 (17). In the crystal, mol-ecules are linked via weak C-H⋯O hydrogen bonds into sheets parallel to the ac plane.
Related Concept Videos
Preparation and Reactions of Sulfides
Phase II Reactions: Methylation Reactions
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Carboxylic Acids to Methylesters: Alkylation using Diazomethane
IUPAC Nomenclature of Aldehydes
Diazonium Group Substitution: –OH and –H


