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1,3-Bis(chloro-meth-yl)benzene.

Marisa B Sanders¹, David Leon, Eddy I Ndichie

¹Department of Chemistry, The College of New Jersey, 2000 Pennington Rd, Ewing, NJ 08628, USA.

Acta Crystallographica. Section E, Structure Reports Online

|September 19, 2013

Summary

This summary is machine-generated.

The pharmaceutical intermediate C8H8Cl2 forms a 3D network in the solid-state. This network is stabilized by chlorine-chlorine interactions, influencing its chemical properties and applications.

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Area of Science:

Solid-state chemistry
Crystallography
Organic synthesis

Background:

The title compound, C8H8Cl2, is a key intermediate in synthesizing various pharmaceutical compounds.
Understanding the solid-state structure of such intermediates is crucial for optimizing synthesis and predicting reactivity.

Purpose of the Study:

To investigate the solid-state structure of C8H8Cl2.
To identify and characterize non-covalent interactions governing the crystal packing.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the three-dimensional molecular structure.
Analysis of intermolecular distances and angles to identify significant interactions.

Main Results:

C8H8Cl2 forms an extended three-dimensional network in the solid-state.
The network is primarily stabilized by chlorine-chlorine interactions, with distances of 3.513(1) Å and 3.768(3) Å.

Conclusions:

Chlorine-chlorine interactions play a significant role in the crystal engineering of C8H8Cl2.
The identified solid-state structure provides insights into the compound's behavior in pharmaceutical synthesis.