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Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

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Systemic karyomegaly with primary pulmonary presentation.

Damian J Tagliente¹, Jesse S Voss, Steve G Peters

¹Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.

Human Pathology

|September 20, 2013

Summary

This summary is machine-generated.

Systemic karyomegaly, a kidney disorder, can affect the lungs. This case reveals enlarged, abnormal cells in lung tissue, expanding diagnostic possibilities for interstitial lung disease.

Keywords:

Interstitial lung disease Karyomegalic interstitial nephritis Systemic karyomegaly

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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

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Published on: November 4, 2015

Area of Science:

Pathology
Pulmonology
Nephrology

Background:

Systemic karyomegaly is a rare disorder defined by renal failure and enlarged renal tubular epithelial cells.
Primary pulmonary involvement in systemic karyomegaly has not been previously documented.

Observation:

A 33-year-old woman presented with progressive restrictive lung disease requiring lung transplantation.
Post-transplant, she experienced graft dysfunction, respiratory decline, and renal failure, leading to death.
Autopsy revealed karyomegalic cells in the kidneys, native lung (alveolar epithelium and airway walls), and other tissues.

Findings:

This study presents the first detailed characterization of karyomegalic cells in lung tissue.
DNA ploidy studies indicated an abnormal ploidy status in these cells.
Viral studies were negative, ruling out a viral etiology.

Implications:

This case expands the understanding of systemic karyomegaly, demonstrating its potential for primary pulmonary presentation.
It broadens the differential diagnosis for interstitial lung disease in young patients.
Further research into the pathogenesis and cellular characteristics of systemic karyomegaly is warranted.