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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
Regulatory T cells in nonlymphoid tissues.
Dalia Burzyn1, Christophe Benoist, Diane Mathis
1Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Nature Immunology
|September 20, 2013
Summary
Regulatory T cells (Treg cells) reside in tissues, exhibiting unique phenotypes and functions beyond immune modulation. This review explores their origins, characteristics, and roles in health and disease.
Area of Science:
- Immunology
- Cell Biology
Background:
- Foxp3(+)CD4(+) regulatory T cells (Treg cells) are crucial for immune homeostasis.
- Local immune responses in nonlymphoid tissues are vital for tissue health.
- The intersection of Treg cell biology and nonlymphoid tissue immunity is a rapidly emerging field.
Purpose of the Study:
- To review recent findings on nonlymphoid tissue-resident Treg cells.
- To discuss the origin, phenotype, and function of tissue Treg cells.
- To highlight current knowledge gaps regarding tissue Treg cells.
Main Methods:
- Literature review of recent studies on Treg cells in nonlymphoid tissues.
- Analysis of data on Treg cell phenotype and function in various tissues.
- Synthesis of information on Treg cell origin and memory.
Main Results:
- Treg cells are found in diverse nonlymphoid tissues during health and disease.
- Tissue-resident Treg cells display unique phenotypes and functions.
- Treg cells in nonlymphoid tissues may represent distinct functional or phenotypic subtypes.
Conclusions:
- Treg cells play multifaceted roles within nonlymphoid tissues.
- Further research is needed to fully understand tissue-resident Treg cell biology.
- Tissue Treg cells offer new avenues for classifying the Treg cell compartment.
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