Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ioxilan, a third generation low osmolality nonionic contrast medium. Systemic and renal hemodynamic effects.

R W Katzberg1, L A Donahue, T W Morris

  • 1Department of Radiology, University of Rochester Medical Center, New York.

Investigative Radiology
|January 1, 1990
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracranial hematolymphoid malignancies: A case series with molecular characterization.

Clinical neurology and neurosurgery·2023
Same author

Fusarium Wilt Caused by Fusarium oxysporum on Lettuce in Espirito Santo, Brazil.

Plant disease·2019
Same author

First Report of Bacterium and Yeasts Associated with Pineapple Fruit Collapse in Espírito Santo State, Brazil.

Plant disease·2019
Same author

First Report of Turnip mosaic virus on Watercress in Brazil.

Plant disease·2019
Same author

First Report of Sexual Reproduction of Fusarium solani f. sp. piperis in Bahia, Brazil.

Plant disease·2019
Same author

Range expansion of the invasive insect Greenidea (Trichosiphon) psidii (Hemiptera: Aphididae) in the Neotropical Region.

SpringerPlus·2016

Ioxilan, a new nonionic contrast media (CM), demonstrated biological equivalence to Iohexol in canine studies. This low osmolality CM offers good tolerance and effective imaging, presenting a promising alternative for radiologists.

Area of Science:

  • Radiology
  • Pharmacology
  • Medical Imaging

Background:

  • Radiologists face a choice between high-cost, low-toxicity nonionic contrast media (CM) and lower-cost ionic CM.
  • Ioxilan is a novel, third-generation nonionic CM derived from an ionic CM, designed for low osmolality (570 mOsm at 300 mgI/ml).

Purpose of the Study:

  • To evaluate the effects of Ioxilan, a low osmolality nonionic CM, on canine systemic and renal hemodynamics compared to Iohexol.
  • To assess the safety and efficacy of Ioxilan for radiographic imaging.

Main Methods:

  • Intravenous (IV) bolus injections of Iohexol and Ioxilan (350 mgI/ml at 2 ml/kg) were administered to canines.
  • Systemic and renal hemodynamics were monitored.
  • Nephrograms and pyelograms were obtained and compared.

Related Experiment Videos

Main Results:

  • Both Iohexol and Ioxilan produced satisfactory nephrograms and pyelograms with no significant differences in image quality.
  • The effects of both CM on systemic and renal hemodynamics were minimal and statistically equivalent.
  • Ioxilan demonstrated good biological tolerance.

Conclusions:

  • Ioxilan and Iohexol are biologically equivalent in terms of acute systemic and renal responses and radiographic image quality.
  • The molecular design of Ioxilan achieves very low osmolality while ensuring good biological tolerance.
  • Ioxilan represents an economically promising, low osmolality nonionic CM option for radiologists.