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Hepatocyte growth factor - the earliest marker of myocardial injury in ST-segment elevation myocardial infarction
Anna Konopka1, Jadwiga Janas, Walerian Piotrowski
1Intensive Cardiac Therapy Clinic, Institute of Cardiology, Warsaw, Poland. akonopka@ptkardio.pl.
Insights
Hepatocyte growth factor (HGF) is an early indicator of myocardial infarction (MI). HGF levels rise rapidly after MI onset and return to normal quickly, aiding in early diagnosis.
Area of Science:
- Cardiology
- Biochemistry
- Medical Diagnostics
Background:
- Hepatocyte growth factor (HGF) levels increase within hours of myocardial infarction (MI).
- Early detection of MI is crucial for timely intervention and improved patient outcomes.
Purpose of the Study:
- To measure human HGF (hHGF) plasma concentrations in the 24 hours following ST-elevation myocardial infarction (STEMI).
- To determine the association between hHGF levels and the odds of experiencing STEMI.
- To establish normal hHGF concentration ranges in healthy individuals.
Main Methods:
- Studied 73 STEMI patients and 11 healthy volunteers.
- Collected blood samples from STEMI patients upon admission and 24 hours later for hHGF analysis.
Main Results:
- Median hHGF in healthy subjects was 666 pg/mL.
- STEMI patients exhibited peak hHGF levels upon initial measurement.
- A 1 pg/mL increase in hHGF correlated with a 0.2% rise in STEMI odds.
Conclusions:
- hHGF emerges as the earliest rising biomarker in acute MI.
- hHGF levels normalize rapidly after acute myocardial infarction.
Background:
Hepatocyte growth factor (HGF) concentration increases in the first few hours of myocardial infarction (MI).
Aim:
(1) To illustrate human HGF (hHGF) plasma concentration during the first 24 h of ST segment elevation myocardialinfarction (STEMI); (2) To estimate the odds ratio of STEMI in the context of hHGF measurements; (3) To describe the normalconcentration of hHGF in healthy subjects.
Methods:
The study groups consisted of 73 STEMI patients and 11 healthy volunteers. In all the patients, we took bloodsamples for hHGF twice, i.e. on admission to hospital and 24 h later.
Results:
The median value of hHGF in healthy volunteers was 666 pg/mL (576; 760 pg/mL). In STEMI, the highest values of hHGF were observed in the first measurement. An increase of 1 pg/mL in hHGF level increased STEMI odds ratio by 0.2%.
Conclusions:
In acute MI, of the known biomarkers, hHGF rises the earliest and very promptly returns to normal values.
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