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Related Experiment Video

Updated: May 7, 2026

Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels
08:37

Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels

Published on: July 3, 2025

Renal adaptation during hibernation.

Alkesh Jani1, Sandra L Martin, Swati Jain

  • 1Univ. of Colorado Denver and the Health Sciences Center, Division of Renal Diseases and Hypertension, Box C281, 12700 East 19th Ave., Research 2, Aurora, CO 80262. Alkesh.Jani@UCDenver.edu.

American Journal of Physiology. Renal Physiology
|September 20, 2013
PubMed
Summary
This summary is machine-generated.

Hibernators exhibit remarkable kidney adaptations to survive extreme cold and low blood flow. Understanding these protective mechanisms could advance therapies for organ injury in cold storage and transplantation.

Keywords:
electrolyteshibernationkidneymetabolismtorpor

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Establishment of Deep Hypothermic Circulatory Arrest in Rats
08:39

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Published on: December 16, 2022

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Last Updated: May 7, 2026

Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels
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Published on: July 3, 2025

Establishment of Deep Hypothermic Circulatory Arrest in Rats
08:39

Establishment of Deep Hypothermic Circulatory Arrest in Rats

Published on: December 16, 2022

Area of Science:

  • Physiology
  • Renal Biology
  • Comparative Mammalian Biology

Background:

  • Hibernators experience significant physiological changes, including reduced metabolic rate, heart rate, respiratory rate, and body temperature.
  • These changes lead to hypoperfusion and hypothermia, posing challenges to organ function.

Purpose of the Study:

  • To review the effects of hibernation-induced hypoperfusion and hypothermia on kidney function.
  • To explore renal adaptations that protect against organ injury during hibernation.

Main Methods:

  • Review of existing literature on hibernation physiology and renal function.
  • Analysis of adaptations in renal architecture, vasculature, and the renin-angiotensin system.

Main Results:

  • Hibernation profoundly affects glomerular filtration and renal plasma flow.
  • Specific adaptations in renal structure and the renin-angiotensin system are observed.
  • Upregulation of protective mechanisms aids in preventing renal injury.

Conclusions:

  • Hibernating mammals possess unique renal adaptations to tolerate extreme hypothermia and hypoperfusion.
  • These adaptations offer valuable insights into potential therapeutic strategies for organ protection during cold storage and transplantation.