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Related Experiment Video

Updated: May 7, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Multiple myeloma presenting as gingival hyperplasia.

Sanjeev Jain¹, Harjit Kaur, Gaurav Kansal

¹Department of Periodontology and Oral Implantology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.

Journal of Indian Society of Periodontology

|September 20, 2013

Summary

Generalized gingival enlargement can be a rare initial sign of multiple myeloma (a plasma cell cancer). This case highlights the importance of investigating systemic diseases like multiple myeloma in patients with unexplained gingival hyperplasia.

Keywords:

Gingival enlargement multiple myeloma plasma cells

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Area of Science:

Oral pathology
Hematology
Oncology

Background:

Multiple myeloma is a plasma cell malignancy.
Oral manifestations are uncommon initial symptoms.
Gingival enlargement is a rare presentation.

Observation:

A 58-year-old male presented with 6 months of generalized gingival enlargement.
Initial clinical diagnosis was gingival hyperplasia.
Histopathology revealed plasma cell infiltration.

Findings:

Biopsy showed stratified squamous epithelium with ulceration.
Subepithelial infiltration by binucleate and multinucleate plasma cells.
Cytoplasmic inclusion bodies were noted in plasma cells, leading to a multiple myeloma diagnosis.

Implications:

Gingival hyperplasia can be an early indicator of multiple myeloma.
Systemic workup is crucial for unexplained gingival enlargement.
Early diagnosis of multiple myeloma improves patient outcomes.