Related Experiment Video
Updated: May 7, 2026
09:40
Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
Function and expression of prolyl hydroxylase 3 in cancers
Qiu-Long Liu1, Qi-Lian Liang, Zhou-Yu Li
1Department of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.
Archives of Medical Science : AMS
|September 20, 2013
Summary
Prolyl hydroxylase 3 (PHD3) suppresses tumor growth and metastasis by targeting hypoxia-inducible factor (HIF). This research highlights PHD3 as a potential tumor suppressor gene and a novel therapeutic target for cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Hypoxia-inducible factor (HIF) promotes tumor progression, aggressiveness, and metastasis under low oxygen conditions.
- Prolyl hydroxylase 3 (PHD3) is induced by hypoxia and hydroxylates HIF-1α.
- PHD3 exhibits diverse biological functions beyond HIF-1α hydroxylation.
Purpose of the Study:
- To investigate the role of Prolyl hydroxylase 3 (PHD3) in tumor biology.
- To elucidate the mechanisms by which PHD3 influences tumor growth, angiogenesis, differentiation, metastasis, and apoptosis.
- To evaluate the potential of PHD3 as a tumor suppressor gene and therapeutic target.
Main Methods:
- The study likely involved in vitro and in vivo experiments to assess PHD3 expression and function in tumor cells.
- Analysis of PHD3's interaction with HIF-1α and its downstream targets.
- Evaluation of tumor growth, angiogenesis, metastasis, and apoptosis in models with modulated PHD3 levels.
Main Results:
- PHD3 demonstrates significant roles in suppressing tumor growth, angiogenesis, differentiation, and metastasis under hypoxic conditions.
- PHD3 actively promotes tumor cell apoptosis in low-oxygen environments.
- PHD3's multifaceted functions suggest its critical involvement in cancer suppression.
Conclusions:
- PHD3 acts as a crucial suppressor of tumor progression and aggressiveness.
- PHD3 holds promise as a novel tumor suppressor gene.
- Targeting PHD3 may represent a new therapeutic strategy for investigating and treating tumors.
Related Concept Videos
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:12Loss of Tumor Suppressor Gene Functions
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...