Related Experiment Video

Updated: May 7, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

High temperature requirement A1 in placental tissues and serum from pre-eclamptic pregnancies with or without fetal

Lu Zong1, Lijuan Wang, Pu Huang

  • 1Department of Gynecology and Obstetrics, First Affiliated Hospital, Medical School, Xi'an Jiaotong University, China.

Archives of Medical Science : AMS
|September 20, 2013
PubMed

Insights

High temperature requirement A1 (HtrA1) shows increased expression in pre-eclampsia (PE) placentas and is linked to fetal growth restriction. Elevated serum HtrA1 levels in PE pregnancies may indicate its role in the condition's development.

Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Biology
  • Pathology

Background:

  • Pre-eclampsia (PE) is a severe pregnancy syndrome with potential risks for mother and fetus.
  • High temperature requirement A1 (HtrA1) is investigated for its role in PE pathogenesis.

Purpose of the Study:

  • To determine the role of HtrA1 in pre-eclampsia.
  • To analyze HtrA1 expression in PE pregnancies and its correlation with fetal growth restriction.

Main Methods:

  • Study included 100 pregnancies with PE and 100 normal controls.
  • Serum HtrA1 levels and fetal growth were recorded.
  • Placental tissues were analyzed post-delivery.

Main Results:

  • HtrA1 expression was higher in PE placentas, increasing from control to PE with appropriate-for-gestational-age (AGA) and PE with fetal growth restriction (FGR) groups.
  • Early-onset PE was more frequent in PE with AGA, while late-onset PE was more common in PE with AGA.
  • Serum HtrA1 levels were significantly elevated in PE with AGA and PE with FGR between 28-32 weeks gestation compared to controls.

Conclusions:

  • HtrA1 may influence trophoblast migration and invasion, contributing to shallow placentation in PE.
  • HtrA1 appears to play a significant role in the etiology and severity of PE and FGR.
  • Further research is needed to elucidate the precise mechanisms of HtrA1 in PE.
Abstract

Keywords:
etiologyfetal growth restrictionhigh temperature requirement A1pre-eclampsiapregnancy

More Related Videos

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Requirements for Human Life01:26

Requirements for Human Life

The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Temperature Measurement Sites01:14

Temperature Measurement Sites

A thermometer measures body temperature. The common sites for measuring body temperature are the oral cavity, axillary region, temporal artery, and skin surface, such as the forehead, abdomen, and axilla. True core body temperature is assessed in the rectum, tympanic membrane, pulmonary artery, esophagus, and urinary bladder.
Oral: When assessing oral temperature, the thermometer tip should be placed under the tongue in the posterior sublingual pocket. It offers accurate readings and can be...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...