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Related Concept Videos

Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

Updated: May 7, 2026

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons
09:36

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons

Published on: May 12, 2014

Reshaping the brain: direct lineage conversion in the nervous system.

Ryoji Amamoto1, Paola Arlotta

  • 1Department of Stem Cell and Regenerative Biology Sherman Fairchild Building 7 Divinity Avenue, Harvard University, Cambridge, MA 02138.

F1000Prime Reports
|September 20, 2013
PubMed
Summary

Differentiated cells can be directly converted into other cell types, like neurons, bypassing intermediate stages. This direct lineage conversion offers new therapeutic possibilities in regenerative medicine.

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Related Experiment Videos

Last Updated: May 7, 2026

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons
09:36

Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons

Published on: May 12, 2014

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes
11:42

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

Published on: June 10, 2021

Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes
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Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes

Published on: July 7, 2022

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Cellular Reprogramming

Background:

  • Embryonic development involves epigenetic changes that lead to cell differentiation.
  • Fully differentiated cells can revert to a pluripotent state via nuclear reprogramming.
  • Direct lineage conversion allows cell type changes without intermediate progenitor cells.

Purpose of the Study:

  • To review recent advancements in direct lineage reprogramming of differentiated cells into neurons.
  • To explore the therapeutic implications of direct neuronal conversion.

Main Methods:

  • Review of current literature on direct lineage reprogramming techniques.
  • Focus on methods achieving direct conversion to neuronal cell types.

Main Results:

  • Significant progress has been made in directly converting various differentiated cells into neurons.
  • These methods bypass the need for pluripotent or progenitor intermediates.

Conclusions:

  • Direct lineage conversion represents a powerful approach for generating specific cell types, particularly neurons.
  • This technology holds considerable promise for future therapeutic applications in regenerative medicine and neurological disorders.