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Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
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Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
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Factors Affecting Perceptual Threshold in Argus II Retinal Prosthesis Subjects.

A K Ahuja1, J Yeoh, J D Dorn

  • 1Second Sight Medical Products, Inc., Sylmar, CA ; Doheny Eye Institute, Keck School of Medicine, Los Angeles, CA.

Translational Vision Science & Technology
|September 20, 2013
PubMed
Summary
This summary is machine-generated.

The Argus II retinal prosthesis

Keywords:
retinal degenerationretinal prosthesisretinitis pigmentosa

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Neuroscience

Background:

  • The Argus II epiretinal prosthesis aims to restore partial vision in patients with outer retinal degenerative diseases.
  • A multicenter clinical trial was conducted to evaluate the device's efficacy and identify factors influencing its performance.

Purpose of the Study:

  • To determine factors affecting electrical thresholds for the Argus II system.
  • To inform optimal surgical placement of the epiretinal prosthesis.

Main Methods:

  • Electrical thresholds were measured by varying current amplitude.
  • Electrode-retina and electrode-fovea distances were assessed using SD-OCT and fundus photography.
  • Regression analysis was used to correlate electrical thresholds with distance and light perception.

Main Results:

  • Significant correlation found between electrical threshold and electrode-retina distance (R² = 0.50, P = 0.0002).
  • Macular contact of electrodes (n = 207) elicited percepts at low charge densities (< 1 mC/cm²/phase).
  • Multivariate modeling showed electrode-retina distance and light threshold are highly predictive of electrode threshold (R² = 0.87).

Conclusions:

  • Macular contact of the Argus II array is critical for device function.
  • Light threshold can aid in patient selection for the retinal prosthesis.
  • Study findings support the development of higher-density, smaller-electrode systems.