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Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance

Keval Chandarana1, Cigdem Gelegen, Elaine E Irvine

  • 1Centre for Obesity Research, Department of Medicine, University College London, Rayne Institute, 5 University Street, WC1E 6JJ, London, UK.

Molecular Metabolism
|September 20, 2013
PubMed

Keywords:
AUC, area under the curveCNS, central nervous systemDPP-4, di-peptidyl peptidase-4EGA, entero-gastric anastomosisGLP-1Glucose homeostasisHFD, high-fat dietICV, intracerebroventricularIPGTT, intraperitoneal glucose tolerance testPYYPYY, peptide tyrosine–tyrosineT2DM, type 2 diabetes mellitusWT, wild-typeY2-receptorY2R, Y2-receptoraCSF, artificial cerebrospinal fluidactive GLP-1, glucagon-like peptide-1(7-36)amideip, intraperitoneal

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