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Analytical evaluation of urinary excretion of furosemide in barrows
A C Ray1, T D Tanksley, D C LaRue
1Texas Veterinary Medical Diagnostic Laboratory, The Texas A&M University System, Drawer 3040, College Station, TX 77841-3040, USA.
Abstract:
Market weight barrows were dosed with furosemide IM or orally, and urine (5 barrows) and blood (1 barrow) samples were collected. Extraction procedures and high-performance liquid chromatographic conditions were modified and adapted for analysis of porcine samples. Furosemide was cleared rapidly from plasma, but could be detected in urine 4 to 5 days after administration, using fluorescent or ultraviolet detection. Fluorescent detection was the preferred method for screening for furosemide. Approximately 12% of furosemide was excreted as the glucuronide conjugate.
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