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Related Experiment Videos

Acetate intolerance during hemodialysis.

A Novello, R C Kelsch, R E Easterling

    Clinical Nephrology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Acetate is often used in hemodialysis, but some patients may not tolerate it. High plasma acetate levels were observed in some individuals, indicating it may not fully correct the buffer imbalance in chronic renal failure.

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    Area of Science:

    • Nephrology
    • Biochemistry

    Background:

    • Acetate is a common substitute for bicarbonate in hemodialysis solutions for patients with chronic renal failure.
    • Chronic renal failure is often associated with a buffer anion deficit.

    Purpose of the Study:

    • To investigate plasma acetate and bicarbonate concentrations in patients undergoing hemodialysis with acetate-containing dialysate.
    • To assess the efficacy of acetate in correcting the buffer anion deficit in chronic renal failure.

    Main Methods:

    • Nine patients with chronic renal failure were enrolled.
    • Plasma acetate and bicarbonate levels were measured during hemodialysis using dialysate containing acetate.

    Main Results:

    • Plasma acetate concentrations exceeded 15 mEq/liter in three patients (two children and one adult) during dialysis.

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  • The study suggests that acetate intolerance may occur due to multiple mechanisms.

    • Conclusions:

    • Hemodialysis with acetate-containing solutions may not fully restore the buffer anion deficit in all patients with chronic renal failure.
    • Acetate intolerance can occur, and its mechanisms are likely multifactorial.