Related Experiment Video

Updated: May 7, 2026

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
14:10

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

Salmonella enteritidis ventriculitis

A J Johan1, L C Hung, O Norlijah

  • 1Department of Pediatric, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor. johan@medic.upm.edu.my

The Southeast Asian Journal of Tropical Medicine and Public Health
|September 21, 2013
PubMed

Insights

Salmonella meningitis in Malaysian infants can relapse, even after prolonged antibiotic treatment. This case highlights challenges in treating ventriculitis and determining optimal antibiotic duration for Salmonella enteritidis infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Neonatal Neurology
  • Microbiology

Background:

  • Salmonella species are a significant cause of meningitis in neonates and young children, particularly in Malaysia.
  • Bacterial meningitis in infants requires prompt and effective antimicrobial therapy.

Observation:

  • A six-week-old female infant presented with Salmonella enteritidis meningitis, initially treated unsuccessfully with a third-generation cephalosporin.
  • The patient experienced a relapse of meningitis, complicated by ventriculitis and hydrocephalus, necessitating an extended eleven-week course of meropenem.

Findings:

  • Clinical improvement was observed with meropenem, but cerebrospinal fluid (CSF) glucose levels remained persistently low.
  • The lack of CSF glucose normalization despite prolonged meropenem treatment indicates potential challenges in eradicating Salmonella enteritidis ventriculitis.

Implications:

  • This case underscores the diagnostic and therapeutic dilemmas in managing recurrent Salmonella meningitis and ventriculitis in neonates.
  • Determining the optimal duration of antibiotic therapy for Salmonella enteritidis ventriculitis remains a clinical challenge, potentially impacting long-term neurological outcomes.

More Related Videos

Chronic Salmonella Infected Mouse Model09:01

Chronic Salmonella Infected Mouse Model

Published on: May 31, 2010

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Related Concept Videos

Reservoir of Infection01:30

Reservoir of Infection

Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...